HCID 9938796, compound → RGX-104 HCl

HRID 1296972Notes

Reaction equation

C[O:2][C:3](=[O:43])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH2:13][C@H:14]([N:16]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[C:33]=2[Cl:42])[CH2:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH3:15])[CH:6]=1.COC(=O)CC1C=CC=C(OC[C@H](C)CN(CC2C=CC=C(C(F)(F)F)C=2Cl)CC(C2C=CC=CC=2)C2C=CC=CC=2)C=1>>[ClH:42].[Cl:42][C:33]1[C:34]([C:38]([F:39])([F:40])[F:41])=[CH:35][CH:36]=[CH:37][C:32]=1[CH2:31][N:16]([CH2:17][CH:18]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C@H:14]([CH3:15])[CH2:13][CH2:12][O:11][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([OH:43])=[O:2])[CH:10]=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 9938796HCID 9938796, compound

HCID 68865342HCID 68865342, compound

Product 1

HCID 68861574RGX-104 HCl

Procedure

Following the procedure of Example 44 step(e) except (R)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methyl-propoxy}-phenyl)acetic acid methyl ester was used in step 44(e) instead of (R)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)acetic acid methyl ester the title compound was isolated to give a white solid (100 mg, 89%). MS(ESI) 596.0 (M+).

Sources & evidence

ORD record: ord-0a26cd0cd7984652939392ab95fefd8c
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07247748B2

Reaction notes

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