Benzyl Alcohol → HCID 17825616, compound

Participants

Reaction Steps

403 mg (10.1 mmol) of sodium hydride (60% oily) was added to 1.102 g (10.2 mmol) of benzyl alcohol in 15 ml of DMF, and they were stirred for 30 minutes. 2.51 g (9.99 mmol) of ethyl 8-bromooctanoate was dissolved in 5 ml of DMF, and the obtained solution was added dropwise to the reaction mixture in ice bath. After stirring at room temperature for 1.5 hours, 2 N hydrochloric acid was added to the mixture. DMF was evaporated under reduced pressure. After the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by the silica gel chromatography (hexane/ethyl acetate=9/1/) to obtain the title compound.

Provenance & Evidence