HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 17825628, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydracrylonitrile | HCID 8011 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Carboxybenzaldehyde | HCID 12077 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 17825628 | HCID 17825628 | — |
Reaction Steps
1.51 g (10.0 mmol) of 3-carboxybenzaldehyde, 1.85 g (26.0 mmol) of ethylene cyanohydrin, 4.99 g (26.2 mmol) of WSC hydrochloride, 1.82 ml (13.1 mmol) of triethylamine and 1.49 g (11.0 mmol) of HOBt were stirred in 20 ml of dichloromethane at room temperature overnight. 1 N hydrochloric acid was added to the reaction mixture. After extraction with dichloromethane, the organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247645B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-ee75fa60160d4df1bd286d78ed1249d7 |
| Source note | uspto-grants-2007_07 |