HCID 17825638, compound → HCID 17825661, compound

HRID 1297042Notes

Reaction equation

HRID 1297042 reaction equation
C([O:8][CH2:9][CH2:10][CH2:11][O:12][CH2:13][C:14](=[O:34])[CH2:15][C:16]([O:18][CH2:19][CH2:20][CH:21]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][CH2:11][O:12][CH2:13][C:14](=[O:34])[CH2:15][C:16]([O:18][CH2:19][CH2:20][CH:21]([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:17]

Participants

4

Reactant 1

HCID 17825638HCID 17825638, compound

Product 1

HCID 17825661HCID 17825661, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4.33 g (9.41 mmol) of 3,3-diphenylpropyl 4-(3-benzyloxypropoxy)-3-oxobutanoate was hydrogenated in the presence of a catalytic amount of 5% palladium/carbon in 50 ml of ethanol under 5 atm. for 14 days. After an ordinary after treatment followed by the purification by the silica gel chromatography (hexane/ethyl acetate=1/1), the title compound was obtained.

Workup

  1. customAfter an ordinary after treatment followed by the purification by the silica gel chromatography (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-0d5d2dff173c4cb8bc2fb811f1594afa
Source dataset
uspto-grants-2007_07
Patent number
US07247645B2

Reaction notes

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