Water → HCID 9902426, compound

Participants

Reaction Steps

Add dropwise under an inert atmosphere 400 μl of iodopropane to a solution of 200 mg (0.675 mmol) of 7,8-dimethoxy-1-phenyl-3,5-dihydro-4H-2,3-benzodiazepin-4-one VIaa and 121 mg (0.878 mmol) of K2CO3 in solution in 5 ml of DMF. After 72 hours at room temperature, add 30 ml of H2O and extract three times with 30 ml of Et2O. Dry the organic fractions on Na2SO4. Purify by chromatography (AcOEt 1/hexane 1). Yield: 72%. M: 48–52° C. 1H-NMR (300 MHz, CDCl3): d 0.83 (t, J=7.34, 3H, CH3), 1.65–1.72 (m, 2H, CH2CH3), 2.85–3.62 (m, 4H, CH2CH2CH3+5-CH2), 3.74 (s, 3H, OCH3), 3.98 (s, 3H, OCH3), 6.67 (s, 1H Ar), 6.89 (s, 1H Ar), 7.43–7.47 (m, 3H Ar), 7.65–7.68 (m, 2H Ar).

Provenance & Evidence