HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 10179379, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-Heptyne | HCID 12350 | — |
| Reactant | HCID 10160160 | HCID 10160160 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 10179379 | HCID 10179379 | — |
Reaction Steps
Stir for 3 hours at room temperature under an inert atmosphere a mixture of 1-(4-iodophenyl)-7,8-dimethoxy-3-methyl-3,5-dihydro-4H-2,3-benzodiazepin-4-one IIIah, 12 mg of CuI, 7 mg of PdCl2, 23 mg of PPh3, 2 ml of TEA, 4 ml of heptyne, in 12 ml of CH3CN. Evaporate to dryness and purify by silica chromatography (AcOEt 1/hexane 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250410B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-0d4379f551d94a408424593a6dfffada |
| Source note | uspto-grants-2007_07 |