Methyl iodide → 6,7-Dimethoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione

Participants

Reaction Steps

To a solution of 500 mg (3.06 mmol) of 6,7-dimethoxy-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione (XV), in 6 ml of anhydrous DMF, add under an inert atmosphere 134 mg (3.37 mmol) of 60% NaH in oil. After 10 minutes at room temperature, add dropwise 219 μl (3.52 mmol) of MeI. Allow to stand at room temperature for 3 hours.

Provenance & Evidence