HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,7-Dimethoxy-2H-3,1-benzoxazine-2,4(1H)-dione → 7,8-dimethoxy-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,7-Dimethoxy-2H-3,1-benzoxazine-2,4(1H)-dione | HCID 2758423 | — |
| Reactant | 6,7-Dimethoxy-1-methyl-1H-benzo(d)(1,3)oxazine-2,4-dione | HCID 12223292 | — |
| Product | 7,8-dimethoxy-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione | HCID 69460982 | 54% |
Reaction Steps
By replacing 6,7-dimethoxy-1-methyl-11,2-dihydro-4H-3,1-benzoxazine-2,4-dione (XVI) in example XVIIaa by 6,7-dimethoxy-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione (XV) and proceeding in the same manner, the abovenamed product is obtained. Yield: 54%. 1H-NMR (DMSO, 300 MHz): d 3.55 (d, J=5.3, 2H, CH2), 3.77 (s, 6H, 2×OCH3), 6.16 (s, 1H Ar), 6.67 (s, 1H Ar), 8.34 (t, J=5.3, 1H, NH), 10.07 (s, 1H, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07250410B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-6e5486a09fd44b43a3c4e49954c85920 |
| Source note | uspto-grants-2007_07 |