Ammonia → HCID 69462384, compound

Participants

Reaction Conditions

Reaction Steps

To 400 mg (1.55 mmol) of (2-amino-4,5-dimethoxyphenyl)(phenyl)methanone (XXIaa), add dropwise 2.1 ml of HBr 40% by weight in water. Heat at 95° C. for 12 hours. At 0° C. add ammonia to pH=8.9. Add 100 ml H2O and extract three times with 100 ml of CH2Cl2. Dry on MgSO4, evaporate the CH2Cl2 and purify by silica chromatography (AcOEt 1/hexane 4 then 1/1). Yield: 45%. 1H-NMR (CDCl3, 200 MHz): d 3.92 (s, 3H, OCH3), 6.20 (s, 1H Ar), 7.00 (s, 1H Ar), 7.42–7.61 (m, 5H Ar).

Provenance & Evidence