Methyl iodide → HCID 69461240, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaf) in example IIba by 7,8-dimethoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaa), and MeI by ethyl iodide, and proceeding in the same manner, the abovenamed product is obtained. Yield: 62%. M: 86–88° C. 1H-NMR (CDCl3, 200 MHz): d 1.15 (t, 3H, CH3), 3.80 (s, 3H, OCH3), 4.01 (s, 3H, OCH3), 4.03 (AB system, ? d=0.61, JAB=13.9, 2H, —NCH2), 4.30 (AB system, ? d=1.00, JAB=9.98, 2H, CH2), 6.71 (s, 1H Ar), 6.88 (s, 1H Ar), 7.40–7.69 (m, 5H Ar).

Provenance & Evidence