Methyl iodide → HCID 9924639, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaf) in example IIba by 7,8-diethoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIag), and MeI by ethyl iodide, and proceeding in the same manner, the abovenamed product is obtained. Yield: 59%. M: 99–102° C. 1H-NMR (CDCl3, 300 MHz): d 1.11 (t, 3H, CH3), 1.36 (t, 3H, CH3), 1.53 (t, 3H, CH3), 3.93 (q, 2H, OCH2), 3.97 (AB system, ?d=0.67, JAB=14.0, 2H, —NCH2), 4.17 (q, 2H, OCH2), 4.28 (AB system, ?d=0.96 JAB=10.0, 2H, CH2), 6.68 (s, 1H Ar), 6.84 (s, 1H Ar), 7.38–7.64 (m, 5H Ar).

Provenance & Evidence