Methyl iodide → HCID 86760520, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaf) in example IIba by 7,8-diethoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIag), and MeI by ethyl bromoacetate, and proceeding in the same manner, the abovenamed product is obtained. Yield: 55%. M: 160–162° C. 1H-NMR (CDCl3, 200 MHz): d 1.21 (t, 3H, CH3), 1.36 (t, 3H, CH3), 1.50 (t, 3H, CH3), 3.88–4.26 (m, 7H, 3×OCH2+1H CH2) 4.49 (AB system, ? d=0.17, JAB=17.4, 2H, —NCH2), 4.80 (m, 1H CH2), 6.71 (s, 1H Ar), 6.81 (s, 1H Ar), 7.27–7.69 (m, 5H Ar).

Provenance & Evidence