Methyl iodide → HCID 69461358, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaf) in example IIba by 7,8-diethoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIag), and MeI by benzyl bromide, and proceeding in the same manner, the abovenamed product is obtained. Yield: 32%. M: 158–160° C. 1H-NMR (CDCl3, 300 MHz): d 1.33 (t, 3H, CH3), 1.40 (t, 3H, CH3), 3.84–3.95 (m, 3H, OCH2+1H CH2) 4.04 (q, 2H OCH2), 4.87 (m, 1H CH2), 5.15 (AB system, ? d=0.74, JAB=15.4, 2H, —NCH2), 6.58 (s, 1H Ar), 6.81 (s, 1H Ar), 7.07–7.46 (m, 10H Ar).

Provenance & Evidence