Methyl iodide → HCID 10111768, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIaf) in example IIba by 5-(3-bromophenyl)-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIak), and MeI by ethyl iodide, and proceeding in the same manner, the abovenamed product is obtained. Yield: 17%. M: 122–126° C. 1H-NMR (CDCl3, 300 MHz): d 1.14 (s, 3H, CH3), 3.79–3.85 (m, 4H, 1H CH2+OCH3), 3.99 (AB system, ? d=0.62, JAB=13.9, 2H, —NCH2), 4.04 (s, 3H, OCH3), 4.78 (m, 1H, CH2), 6.65 (s, 1H Ar), 6.86 (s, 1H Ar), 7.26–7.31 (m, 2H Ar), 7.52–7.62 (m, 2H Ar), 7.86 (s, 1H Ar).

Provenance & Evidence