Phenylacetylene → HCID 10295930, compound

Participants

Reaction Steps

By replacing 5-(4-bromophenyl)-1-ethyl-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (IIbl) in example IIbn by 5-(3-bromophenyl)-1-ethyl-7,8-dimethoxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one (IIbm), and [(prop-2-ynyloxy)methyl]benzene by phenylacetylene, and proceeding in the same manner, the abovenamed product is obtained. Yield: 33%. M: 100–102° C. 1H-NMR (CDCl3, 200 MHz): d 1.13 (s, 3H, CH3), 3.51–3.82 (m, 5H, 1H NCH2+1H CH2+OCH3), 3.97 (s, 3H, OCH3), 4.24–4.34 (m, 1H, NCH2), 4.74–4.80 (m, 1H, CH2), 6.66 (s, 1H Ar), 6.84 (s, 1H Ar), 7.26–7.83 (m, 9H Ar).

Provenance & Evidence