Pyridine → HCID 69462682, compound

Participants

Reaction Steps

To a solution of 40 mg (0.09 mmol) of 7,8-dimethoxy-1-ethyl-3-(2-aminobenzyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one IIca, add 18.4 mg (0.23 mmol) of pyridine in 4 ml of CH2Cl2, 11.5 mg (0.11 mmol) of acetic anhydride dropwise. Stir for 24 hours. Evaporate to dryness and purify by silica chromatography (AcOEt then AcOEt 5/CH2Cl2 4/EtOH 1). Yield: 70%. M: 144–145° C. 1H-NMR (CDCl3, 300 MHz): d 0.89–0.96 (m, 3H, CH3), 2.01 (s, 1H, COCH3), 3.36–3.45 (m, 2H, CHCH2), 3.61 (s, 3H, OCH3), 3.73–3.84 (m, 2H, CHCH2+1HNCH2), 3.91 (s, 3H, OCH3), 6.60 (s, 1H Ar), 7.07–7.61 (m, 10H Ar). Mass: (M+H)+=472.23.

Provenance & Evidence