HCID 69460802, compound → HCID 69462486, compound

Participants

Reaction Steps

By replacing 7,8-dimethoxy-1-ethyl-3-(2-aminobenzyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (IIca) in example IIcf by 7,8-dimethoxy-1-ethyl-3-(2-aminomethylbenzyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (IIcg) and proceeding in the same manner, the abovenamed product is obtained. Yield: 55%. M: 122–124° C. 1H-NMR (CDCl3, 200 MHz): d 1.07–1.14 (m, 3H, CH3), 1.49 (s, 1H, COCH3), 3.41–3.80 (m, 6H, CHCH2+1HNCH2+OCH3), 3.89–3.98 (m, 4H, CHCH2+OCH3), 4.34–4.45 (m, 1HNCH2), 6.60 (s, 1H Ar), 4.55–4.57 (m, 2H, CH2NHAc), 6.52 (s, 6.85 (s, 1H Ar), 7.18–8.45 (m, 9H Ar), 8.45 (m, 1H, NHAc).

Provenance & Evidence