Methyl iodide → HCID 58983041, compound

HRID 1297141Notes

Reaction equation

HRID 1297141 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1.I[CH3:22]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:12]([CH3:22])[C:11](=[O:13])[CH2:10][N:9]=[C:8]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:7]=2[CH:20]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 99432571,4-BENZODIAZP2-ON,5(PH)7MEO

Product 1

HCID 58983041HCID 58983041, compoundYield 55%

Procedure

By replacing 7,8-dimethoxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (XXIIaa) in the example by 7-methoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIao), and ethylene-carbonate by iodomethane, and proceeding in the same manner, the abovenamed product is obtained. Yield: 55%. M: 10–112° C. 1H-NMR (CDCl3, 300 MHz): d 3.38 (s, 3H, NCH3), 3.75 (s, 3H, OCH3), 4.30 (AB system, ? d=1.00, JAB=10.6, 2H, —CH2), 6.77–6.78 (m, 1H Ar), 7.09–7.14 (m, 1H Ar), 7.31 (s, 1H Ar), 7.38–7.46 (m, 3H Ar), 7.44–7.67 (m, 2H Ar).

Workup

  1. customthe abovenamed product is obtained
  2. custom10–112° C

Sources & evidence

ORD record
ord-9fb9718f19014208af4f76c883d41ac9
Source dataset
uspto-grants-2007_07
Patent number
US07250410B2

Reaction notes

Loading…