Methyl iodide → HCID 15057253, compound

Participants

Reaction Steps

By replacing 7,8-dimethoxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one (XXIIaa) in the example by 7-methoxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (XXIIan), and ethylene carbonate by iodomethane, and proceeding in the same manner, the abovenamed product is obtained. Yield: 76%. M: 114–116° C. 1H-NMR (CDCl3, 300 MHz): d 3.41 (s, 3H, NCH3), 3.90 (s, 3H, OCH3), 4.29 (AB system, ? d=0.99, JAB=10.6, 2H, —CH2), 6.71–6.75 (m, 1H Ar), 6.81–6.82 (m, 1H Ar), 7.22–7.25 (m, 1H Ar), 7.36–7.42 (m, 3H Ar), 7.50–7.62 (m, 2H Ar).

Provenance & Evidence