4-Methylbenzaldehyde → HCID 178490782, compound

Participants

Reaction Steps

This compound was prepared using the methods outlined in Example 27, substituting p-anisaldehyde for p-tolualdehyde and 2-[4-(2-piperidin-4-yl-ethoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide for 2-[4-(2-piperidin-2-yl-ethoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide. HPLC (Method C): Rt=4.49. MS (ESI+): mass calcd. for C29H32N4O3, 484.25; m/z found, 485.4 [M+H]+. 1H NMR (500 MHz, CD3OD): 8.17 (s, 1H), 8.00 (d, J=8.8 Hz, 2H), 7.93 (d, J=8.5 Hz, 1H), 7.69 (d, J=8.5 Hz, 1H), 7.31 (d, J=8.7 Hz, 2H), 7.13 (d, J=8.8 Hz, 2H), 6.92 (d, J=8.7 Hz, 2H), 4.13 (s, 2H), 4.13-4.11 (m, 2H), 3.73 (s, 3H), 3.41-3.38 (m, 2H), 2.94-2.85 (m, 2H), 1.99-1.96 (m, 2H), 1.86-1.79 (m, 1H), 1.79-1.71 (m, 2H), 1.47-1.36 (m, 2H).

Provenance & Evidence