4-Methylbenzaldehyde → HCID 178513583, compound

Participants

Reaction Steps

This compound was prepared using the methods outlined in Example 27, substituting 2-[4-(piperidin-3-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide for 2-[4-(2-piperidin-2-yl-ethoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide and p-chlorobenzaldehyde for p-tolualdehyde. HPLC (Method C): Rt=4.57. MS (ESI+): mass calcd. for C27H27ClN4O2, 474.18; m/z found, 475.3 [M+H]+. 1H NMR (500 MHz, CD3OD): 8.13 (s, 1H), 8.00 (d, J=8.8 Hz, 2H), 7.85 (dd, J=1.5, 8.7 Hz, 1H), 7.63 (d, J=8.5 Hz, 1H), 7.43 (s, 4H), 7.10 (d, J=8.8 Hz, 2H), 4.28-4.27 (m, 2H), 4.08-4.04 (m, 1H), 3.95-3.91 (m, 1H), 3.62-3.57 (m, 1H), 3:45-3.40 (m, 1H), 2.91-2.85 (m, 2H), 2.32-2.24(m, 1H), 2.01-1.89 (m, 2H), 1.80-1.69 (m, 1H), 1.46-1.36 (m, 1H).

Provenance & Evidence