4-Methylbenzaldehyde → HCID 178513584, compound

Participants

Reaction Steps

This compound was prepared using the methods outlined in Example 27, substituting 2-[4-(piperidin-3-ylmethoxy)-phenyl]-1H benzoimidazole-5-carboxylic acid amide for 2-[4-(2-piperidin-2-yl-ethoxy)-phenyl]-1H-benzoimidazole-5-carboxylic acid amide and 3,4-dichlorobenzaldehyde for p-tolualdehyde. HPLC (Method C): Rt=4.79. MS (ESI+): mass calcd. for C27H26Cl2N4O2, 508.14; m/z found, 509.3 [M+H]+. 1H NMR (500 MHz, CD3OD): 8.17 (s, 1H), 8.02 (d, J=9.1 Hz, 2H), 7.92 (dd, J=1.5, 8.7 Hz, 1H), 7.67 (m, 2H), 7.58 (d, J=8.3 Hz, 1H), 7.28 (dd, J=2.0, 8.4 Hz, 1H), 7.13 (d, J=9.1 Hz, 2H), 4.32-4.25 (m, 2H), 4.08-4.05 (m, 1H), 3.98-3.94 (m, 1H), 3.61-3.58 (m, 1H), 3.45-3.41 (m, 1H), 2.92-2.87 (m, 2H), 2.36-2.25 (m, 1H), 2.00-1.90 (m, 2H), 1.81-1.71 (m, 1H), 1.46-1.36 (m, 1H).

Provenance & Evidence