Bromine → HCID 9931305, compound

HRID 129722Notes

Reaction equation

HRID 129722 reaction equation
[Cl:1][C:2]1[C:3]([O:23]C)=[CH:4][C:5]2[CH:11]([C:12]3[C:20]4[O:19][CH2:18][CH2:17][C:16]=4[CH:15]=[CH:14][CH:13]=3)[CH2:10][N:9]([CH3:21])[CH2:8][CH2:7][C:6]=2[CH:22]=1.[Br:25]Br>C(O)(=O)C>[Cl:1][C:2]1[C:3]([OH:23])=[CH:4][C:5]2[CH:11]([C:12]3[C:20]4[O:19][CH2:18][CH2:17][C:16]=4[CH:15]=[C:14]([Br:25])[CH:13]=3)[CH2:10][N:9]([CH3:21])[CH2:8][CH2:7][C:6]=2[CH:22]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 19370238HCID 19370238, compound

Product 1

HCID 9931305HCID 9931305, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

(+) 8-Chloro-5-(2,3-dihydrobenzofuran-7-yl)-7-methoxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (1.0 g, 2.9 mmol) was dissolved in acetic acid (10 ml). To the stirred solution was added bromine (0.20 ml, 4.0 mmol) in acetic acid (5 ml) over a period of 2 h. The mixture was stirred overnight at room temperature. A precipitate was formed. The white solid was filtered and washed with diethylether.

Workup

  1. customA precipitate was formed
  2. filtrationThe white solid was filtered
  3. washwashed with diethylether

Sources & evidence

ORD record
ord-be3d4d0130574acd826ef160f56346ef
Source dataset
uspto-grants-1995_11
Patent number
US05470850

Reaction notes

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