Hydrochloric Acid → 3-(1-aminomethyl-spiro[2.5]oct-1-yl)-4H-[1,2,4]oxadiazol-5-one hydrochloride

HRID 1297230Notes

Reaction equation

HRID 1297230 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1([C:17]2[NH:21][C:20](=[O:22])[O:19][N:18]=2)[C:11]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH2:10]1)(C)(C)C.[ClH:24].CCOCC>O1CCOCC1>[ClH:24].[NH2:7][CH2:8][C:9]1([C:17]2[NH:21][C:20](=[O:22])[O:19][N:18]=2)[C:11]2([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)[CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 136338587(1-(5-Oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-spiro[2.5]oct-1-ylmethyl]-carbamic acid tert-butyl ester

Product 1

HCID 1363385883-(1-aminomethyl-spiro[2.5]oct-1-yl)-4H-[1,2,4]oxadiazol-5-one hydrochlorideYield 64%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of [1-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-spiro[2.5]oct-1-ylmethyl]-carbamic acid tert-butyl ester (4.30 g, 13.3 mmol) in 1,4-dioxane (90 mL) was added 4N HCl in 1,4-dioxane (45 mL). The solution was stirred for 18 hours, ether (200 mL) was added and the precipitate isolated by vacuum filtration. The residue was chromatographed on a wet-packed silica gel column (5.5×30 cm) eluting with 80:20:5 CH2Cl2/MeOH/NH4OH. The appropriate fractions were combined and evaporated under reduced pressure. The solid was stirred with 1N HCl in ether (150 mL). The solid was isolated by vacuum filtration, dried in a vacuum oven at 48° C. to give 2.22 g (64%) of 3-(1-aminomethyl-spiro[2.5]oct-1-yl)-4H-[1,2,4]oxadiazol-5-one hydrochloride as a white solid: mp: 179-181° C. (decomposition); 1H NMR (300 MHz, CD3OD) δ 1.05 (d, J=5.8 Hz, 1H), 1.21 (m, 1H), 1.41 (d, J=5.8 Hz, 1H), 1.4-1.72 (m, 9H), 3.12 (d, J=14 Hz, 1H), 3.54 (d, J=14 Hz, 1H); MS (APCI) m/z 224 [M+H]+. Anal. Calc'd For C11H17N3O2—HCl: C, 50.52; H, 7.01; N, 16.07; Cl, 13.56. Found: C, 50.23; H, 7.05; N, 15.89; Cl, 13.53.

Workup

  1. customthe precipitate isolated by vacuum filtration
  2. customThe residue was chromatographed on a wet-packed silica gel column (5.5×30 cm)
  3. washeluting with 80:20:5 CH2Cl2/MeOH/NH4OH
  4. customevaporated under reduced pressure
  5. stirringThe solid was stirred with 1N HCl in ether (150 mL)
  6. customThe solid was isolated by vacuum filtration
  7. customdried in a vacuum oven at 48° C.

Sources & evidence

ORD record
ord-0796030493de4643abbacf5977de7380
Source dataset
uspto-grants-2007_07
Patent number
US07250433B2

Reaction notes

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