1-(Benzyloxy)-4-iodobenzene → HCID 69299373, compound

HRID 1297265Notes

Reaction equation

HRID 1297265 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[CH:5]2.[CH2:12]([O:19][C:20]1[CH:25]=[CH:24][C:23](I)=[CH:22][CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:21][CH:22]=1)[C:6]([CH3:11])=[CH:5]2

Participants

3

Reactant 2

HCID 5196711-(Benzyloxy)-4-iodobenzeneHCID 27787155-Fluoro-2-methylindole

Product 1

HCID 69299373HCID 69299373, compoundYield 23%

Procedure

5-Fluoro-2-methylindole (5.0 g, 33.5 mmol) and 4-benzyloxy iodobenzene (10.40 g, 33.5 mmol) were reacted according to the procedure used in Example 1a above to afford a white solid (23%): mp 94-95° C.; 1 H NMR (DMSO-d6): δ 2.23 (3H, s), 5.19 (2H, s), 6.39 (1H, s), 6.84-6.94 (2H, m), 7.19-7.29 (3H, m), 7.34-7.44 (5H, m), 7.51 (2H, d,J=7.1 Hz); MS m/z (M+H)+ 332. Anal. for C22H18NOF: Calc'd: C, 79.74; H, 5.47; N, 4.23. Found: C, 79.54; H, 5.54; N, 4.21.

Sources & evidence

ORD record
ord-d58ccf73f96e4042b84f517ac9003fb0
Source dataset
uspto-grants-2007_07
Patent number
US07250440B2

Reaction notes

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