HCID 6610570, compound → HCID 54036333, compound

HRID 129728Notes

Reaction equation

HRID 129728 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[NH:11][C@H:10]([C:12]([OH:14])=O)[CH2:9][S:8]2)[CH:2]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)[O:23][CH2:24][CH2:25][N:26]([CH3:32])C(NC)CC)=[CH:18][CH:17]=1>>[CH3:6][N:1]([CH2:2][CH2:3][CH2:4][N:26]([CH2:25][CH2:24][O:23][CH:22]([C:19]1[CH:18]=[CH:17][C:16]([F:15])=[CH:21][CH:20]=1)[C:33]1[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=1)[CH3:32])[C:12]([C@@H:10]1[CH2:9][S:8][CH:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[NH:11]1)=[O:14]

Participants

3

Reactant 2

HCID 6610570HCID 6610570, compoundHCID 19370350HCID 19370350, compound

Product 1

HCID 54036333HCID 54036333, compoundYield 52%

Procedure

Following a procedure similar to that described in Example 1, but using (4R)-2-(3-pyridyl)thiazolidine-4-carboxylic acid and N-{2-[bis(4-fluorophenyl)methoxy]ethyl}-N-methyl-N'-methylpropanediamine (prepared as described in Preparation 3), the title compound was obtained in a yield of 52%.

Sources & evidence

ORD record
ord-50c4115080144a5995c1d0358e61eda3
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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