2-Methyl-6-methoxypyridine-3-boronic acid → HCID 58914559, compound

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Reaction Steps

Following the procedure for the preparation of benzyl (3R,4S)-3-({5-[6-(dimethylamino)-4-methylpyridin-3-yl]-3,6-diethylpyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate but substituting 6-methoxy-2-methylpyridin-3-ylboronic acid provided the title compound as an oil: 1H NMR (400 MHz, CDCl3) δ) 7.41–7.36, 6.64, 5.17–5.15, 4.78, 4.11, 4.02–3.97, 3.73–3.35, 2.70, 2.46, 2.28, 1.32–1.21, 1.13; IR (liq.) 2236 (w), 2018 (w), 1949 (w), 1709 (s), 1596, 1565, 1499, 1474 (s), 1420 (s), 1396, 1360, 1350, 1304 (s), 1126, 1097 cm−1 HRMS (ESI) calcd for C29H37N5O4+H1 520.2924. found 520.2924.

Provenance & Evidence