反应详情

A mixture of 3 g (12.2 mmole) of 2- (diphenyl-methoxy)ethyl chloride, 5 g (49 mmole) of N,N' -dimethyl-propanediamine and 40 ml of toluene was heated under reflux overnight. At the end of this time, the toluene layer was separated and washed with water; 25 ml of a 10% w/v aqueous solution of acetic acid was then added thereto. The aqueous layer was separated, and a 10% w/v aqueous solution of sodium hydroxide was added to make it alkaline. The mixture was then extracted with diethyl ether, and the solvent was removed by distillation under reuced pressure, to obtain 2.4 g (yield 63%) of the title compound as an oil.

1. temperaturewas heated
2. temperatureunder reflux overnight
3. customAt the end of this time, the toluene layer was separated
4. washwashed with water
5. addition25 ml of a 10% w/v aqueous solution of acetic acid was then added
6. customThe aqueous layer was separated
7. additiona 10% w/v aqueous solution of sodium hydroxide was added
8. extractionThe mixture was then extracted with diethyl ether
9. customthe solvent was removed by distillation under reuced pressure