反应详情

Following the procedure for the preparation of N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting benzyl (3R,4S)-3-({3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate provided the title compound as an amber oil. 1H NMR (CDCl3) δ 1.13, 1.28, 2.41, 2.69, 3.14, 3.37, 3.51, 3.66˜3.75, 4.04, 4.16, 4.69, 5.29, 6.96, 7.54; IR (liq.) 2975 (s), 2417 (b), 2177 (b), 2029 (w), 1923 (w), 1609 (s), 1565 (s), 1479 (s), 1400 (s), 1341 (s), 1278 (s), 1239 (s), 1192 (s), 1177 (s), 1138 (s) cm−1.