2-Bromopyridine → 5-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-[(3R,4S)-4-ethoxy-1-pyridin-2-ylpyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

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Reaction Steps

Following the procedure for the preparation of N-[(3R,4S)-4-ethoxy-1-pyrimidin-2-ylpyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting 2-bromo pyridine and 5-[6-(dimethylamino)-4-methylpyridin-3-yl]-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine provided the title compound as an amporphous solid: 1H NMR (400 MHz, CDCl3) δ) 8.19, 7.99, 7.47, 6.58, 6.46, 6.41, 5.25, 4.90, 4.25, 4.02, 3.80–3.72, 3.55, 3.40, 3.13, 2.70, 2.54, 2.12, 1.29, 1.16; IR (liq.) 2969, 2930, 2871, 2414 (w), 1941 (w), 1602 (s), 1558 (s), 1490 (s), 1474 (s), 1443 (s), 1395 (s), 1374, 1166, 1124, 770 cm−1 HRMS (ESI) calcd for C27H37N7O+H1 476.3138. found 476.3134.

Provenance & Evidence