2-Chloro-4-methoxypyrimidine → 5-(2-chloro-4-methoxyphenyl)-N-[(3R,4S)-4-ethoxy-1-(4-methoxypyrimidin-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

Participants

Reaction Steps

Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine but substituting 5-(2-chloro-4-methoxyphenyl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine and 2-chloro-4-methoxypyrimidine provided the title compound as an amporphous solid: 1H NMR (400 MHz, CDCl3) δ) 8.03, 7.25, 7.02, 6.90, 6.02, 5.25, 4.88, 4.22, 3.92–3.78, 3.55, 2.74, 2.50, 1.33–1.26, 1.16; IR (diffuse reflectance) 2972, 2475 (w), 2350 (w), 2310 (w), 2183 (w), 2069 (w), 1585 (s), 1568 (s), 1516 (s), 1482 (s), 1466 (s), 1397, 1393, 1292, 1231 cm−1 HRMS (ESI) calcd for C26H33N6O3Cl+H1 513.2380. found 513.2356.

Provenance & Evidence