2-Bromopyrimidine → 5-(2-chloro-4-methoxyphenyl)-N-[(3R,4S)-4-ethoxy-1-pyrimidin-2-ylpyrrolidin-3-yl]-3,6-diethyl pyrazin-2-amine

Participants

Reaction Steps

Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine but substituting 2-bromopyrimidine and starting with 5-(2-chloro-4-methoxyphenyl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine provided the title compound as an amorphous solid. 1H NMR (CDCl3) δ 1.17, 1.26–1.34, 2.51, 2.76, 3.54, 3.78, 3.86, 3.97, 4.27, 4.91, 5.25, 6.61, 6.90, 7.02, 7.25, 8.40; IR (diffuse reflectance) 2971, 2392 (w), 2352 (w), 2307 (w), 2265 (w), 2170 (w), 1583 (s), 1569, 1549 (s), 1508 (s), 1481 (s), 1475 (s), 1397, 1392, 1384 cm−1 HRMS (EI) calcd for C25H31ClN6O2 482.2197. found 482.2192.

Provenance & Evidence