5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine → N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine

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Reaction Steps

Following the procedure for the preparation of 5-(2,4-dichlorophenyl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl}-3,6-diethylpyrazin-2-amine but starting with N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine provided the title compound as an amorphous solid. 1H NMR (CDCl3) δ 1.15, 1.30, 2.45, 2.68, 3.48˜3.58, 3.77, 3.88, 4.04, 4.29, 4.94, 5.29, 6.56, 6.98, 7.56; IR (diffuse reflectance) 2974, 2350 (w), 2337 (w), 1921 (w), 1607, 1568, 1538 (s), 1477 (s), 1397, 1342, 1278 (s), 1239, 1192, 1175, 1137 (s) cm−1 HRMS (ESI) calcd for C24H29N6O2SF3+H1 523.2103. found 523.2108.

Provenance & Evidence