Triethylamine → HCID 85866771, compound

Participants

Reaction Steps

Triethylamine (39.02 ml) and sulfur trioxide-pyridine mixture (55.71 g) were added to a DMSO (300 ml) solution of ethyl 6-hydroxymethylthiazolo[3,2-a]benzimidazole-2-carboxylate (19.34 g). The reaction mixture was stirred for 2 hours accompanied by exothermic reaction. After completion of the reaction, the reaction mixture was carefully added to saturated sodium bicarbonate aqueous solution. The insoluble matter was collected by filtration, washed with water and then dried by heating under a reduced pressure to obtain the pale ivory-colored title compound (19.10 g).

Provenance & Evidence