Sodium Hydroxide → HCID 69148958, compound

Participants

Reaction Steps

1-Hydroxybenzotriazole (10.1 g) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (28.8 g) were added to a DMF (500 ml) suspension of 6-hydroxymethylthiazolo[3,2-a]benzimidazole-2-carboxylic acid (12.4 g), and the reaction mixture was stirred at room temperature for 1.5 hours. N-(1,3-Dioxolan-2-ylmethyl)-N-methylamine (17.1 ml) was added to the reaction mixture, and the resulting reaction mixture was stirred at the same temperature for 1 hour. After completion of the reaction, the reaction mixture was poured into 0.5 M sodium hydroxide aqueous solution (2 l). The insoluble matter was collected by filtration, washed with water and then with a mixed solvent of hexane and diethyl ether (mixing ratio; 3:1) and then dried by heating under a reduced pressure to obtain the title compound (8.62 g).

Provenance & Evidence