Ethyl 4-(2-chloroethyl)piperazine-1-carboxylate → HCID 19370307, compound

HRID 129736Notes

Reaction equation

HRID 129736 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([OH:10])[CH3:9])=[CH:4][CH:3]=1.Cl[CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)([O:10][CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH2:22][CH2:21]2)[CH3:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 201594Ethyl 4-(2-chloroethyl)piperazine-1-carboxylateHCID 141899961-(4-Chlorophenyl)-1-phenylethan-1-ol

Product 1

HCID 19370307HCID 19370307, compoundYield 89%

Procedure

Following a procedure similar to that described in Preparation 8(a), but using 1-(4-chlorophenyl)-1-phenylethanol and 1-(2-chloroethyl)-4-(ethoxycarbonyl)piperazine, the title compound was obtained in a yield of 89%.

Sources & evidence

ORD record
ord-e1ca6d9e66014f039b66d91aa5f1a572
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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