Potassium Hydroxide → HCID 19370357, compound

HRID 129737Notes

Reaction equation

HRID 129737 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)([O:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16](C(OCC)=O)[CH2:15][CH2:14]2)[CH3:9])=[CH:4][CH:3]=1.[OH-].[K+]>C(O)CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:24]2[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=2)([O:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 19370381HCID 19370381, compound

Product 1

HCID 19370357HCID 19370357, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

Following a procedure similar to that described in Preparation 8(b), but using 4-{2-[1,1-bis(4-fluorophenyl)ethoxy]ethyl}-1-ethoxycarbonylpiperazine [prepared in a similar manner to that described in Preparation 8(a)], potassium hydroxide and ethylene glycol, the title compound was obtained in a yield of 83%.

Workup

  1. customprepared in a similar manner to that

Sources & evidence

ORD record
ord-f8c8bea423f44a3f954f4e11598377f9
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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