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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 129738Generated: October 25, 2026

Hexahydro-1,4-diazepine → 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-[1,4]diazepane

https://huagongshe.com/reaction/129738

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHexahydro-1,4-diazepineHCID 68163—
Reactant1-[Bis(4-fluorophenyl)methoxy]-2-chloroethaneHCID 10779302—
Product1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-[1,4]diazepaneHCID 1061757388%

Reaction Steps

Following a procedure similar to that described in Preparation 1, but using 2-[bis(4-fluorophenyl)methoxy]ethyl chloride and homopiperazine, the title compound was obtained in a yield of 88%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05470851
Source datasetuspto-grants-1995_11
ORD IDord-1904ea0342004963a8abe8e3efd216a2
Source noteuspto-grants-1995_11