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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297388Generated: October 26, 2026

Ethyl indole-2-carboxylate → 7-Fluoro-1-methylindole-3-carboxaldehyde

https://huagongshe.com/reaction/1297388

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant7-Fluoro-1H-indole-3-carbaldehydeHCID 22139120—
Product7-Fluoro-1-methylindole-3-carboxaldehydeHCID 2213903743%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 7-fluoro-1H-indole-3-carboxaldehyde (0.5 g, 3.1 mmole) for the ethyl indole-2-carboxylate, the title compound (0.23 g, 43%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07250424B2
Source datasetuspto-grants-2007_07
ORD IDord-5ec1d33b02a146e7af9148140ebac303
Source noteuspto-grants-2007_07