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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297389Generated: October 26, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 7-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/1297389

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant7-Fluoro-1-methylindole-3-carboxaldehydeHCID 22139037—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product7-fluoro-1-methyl-3-(methylaminomethyl)-1H-indoleHCID 2213906672%

Reaction Steps

According to the procedure of Preparation 11 (c), except substituting 7-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.23, 1.3 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.18 g, 72%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07250424B2
Source datasetuspto-grants-2007_07
ORD IDord-fa4c7c9c7549415a943cc97fb7d98f36
Source noteuspto-grants-2007_07