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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297409Generated: October 30, 2026

1,3-dimethyl-1H-indole-2-carbaldehyde → 6-Chloro-N,1-dimethyl-1H-indole-3-methanamine

https://huagongshe.com/reaction/1297409

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-dimethyl-1H-indole-2-carbaldehydeHCID 2771468—
Reactant6-chloro-1-methyl-1H-indole-3-carbaldehydeHCID 22139020—
ReactantMethyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139049—
Product6-Chloro-N,1-dimethyl-1H-indole-3-methanamineHCID 2213903993%

Reaction Steps

According to the procedure of Preparation 13 (c), except substituting 6-chloro-1-methyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (2.1 g, 93%) was obtained as an amber oil: MS (ES) m/e 209.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07250424B2
Source datasetuspto-grants-2007_07
ORD IDord-ecea2557d755468f8f84bda611141504
Source noteuspto-grants-2007_07