1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 54142401, compound

HRID 129742Notes

Reaction equation

HRID 129742 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][CH2:13][NH:14][CH2:15][C@H:10]3[C:9]3[CH:16]=[CH:17][CH:18]=[CH:19][C:8]=3[CH2:7][C:6]=2[CH:20]=1.Br[CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]2[C:25]1=[O:34]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][CH2:13][N:14]([CH2:22][CH2:23][N:24]4[C:28](=[O:29])[C:27]5=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]5[C:25]4=[O:34])[CH2:15][C@H:10]3[C:9]3[CH:16]=[CH:17][CH:18]=[CH:19][C:8]=3[CH2:7][C:6]=2[CH:20]=1

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 53917327HCID 53917327, compound

Product 1

HCID 54142401HCID 54142401, compoundYield 47%

Procedure

Following a procedure similar to that described in Preparation 14(a), but using (14bR)-8-chloro-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine and N-(2-bromoethyl)phthalimide, the title compound was obtained in a yield of 47%.

Sources & evidence

ORD record
ord-8fd3275186e24e7c832681c10c4167b9
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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