1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 53891496, compound

HRID 129743Notes

Reaction equation

HRID 129743 reaction equation
[CH2:1]1[C@H:6]2[C:7]3[N:8]([CH:16]=[CH:17][CH:18]=3)[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]2[CH2:4][CH2:3][NH:2]1.Br[CH2:20][CH2:21][N:22]1[C:26](=[O:27])[C:25]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]2[C:23]1=[O:32]>>[C:23]1(=[O:32])[N:22]([CH2:21][CH2:20][N:2]2[CH2:3][CH2:4][N:5]3[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=4[CH2:9][N:8]4[CH:16]=[CH:17][CH:18]=[C:7]4[C@@H:6]3[CH2:1]2)[C:26](=[O:27])[C:25]2=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]12

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 12837719HCID 12837719, compound

Product 1

HCID 53891496HCID 53891496, compound

Procedure

Following a procedure similar to that described in Preparation 14(a), but using (14bS)-1,2,3,4,10,14b-hexahydropyrazino[1,2-a]pyrrolo[2,1-c][1,4]benzodiazepine and N-(2-bromoethyl)phthalimide, the title compound was obtained in a quantitative yield.

Sources & evidence

ORD record
ord-a5f1b35e691846eeb854bb8182d97120
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

Loading…