Ethyl indole-2-carboxylate → Methyl N-methylindole-6-carboxylate

HRID 1297430Notes

Reaction equation

HRID 1297430 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC=CC=2)C=[C:15]1C(OCC)=O>>[CH3:15][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 639844Methyl indole-6-carboxylate

Product 1

HCID 639843Methyl N-methylindole-6-carboxylateYield 95%

Procedure

According to the procedure of Preparation 9 (a), except substituting methyl indole-6-carboxylate for the ethyl indole-2-carboxylate, the title compound (2.5 g, 95%) was obtained as white solid: MS (ES) m/e 190.2 (M+H)+.

Sources & evidence

ORD record
ord-53d045f3e9474ab1a8b66281e3c59f2d
Source dataset
uspto-grants-2007_07
Patent number
US07250424B2

Reaction notes

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