HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1297436Generated: October 30, 2026
1,1'-Carbonyldiimidazole → 6-bromo-3-(2-methoxyethyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one
https://huagongshe.com/reaction/1297436
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine | HCID 22139061 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 6-bromo-3-(2-methoxyethyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one | HCID 22139051 | 83% |
Reaction Steps
1,1′-Carbonyldiimidazole (0.74 g, 4.60 mmole) was added to a solution of 2-amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine (1.00 g, 3.80 mmole) in 1,2-dichloroethane (35 mL) at RT. The reaction was heated at 65° C. with stirring overnight, then was concentrated in vacuo. Flash chromatography on silica gel (5% MeOH/CHCl3) gave title compound (0.90 g, 83%) as a yellow solid after drying in vacuo: MS (ES) m/e 286/288 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07250424B2 |
|---|
| Source dataset | uspto-grants-2007_07 |
|---|
| ORD ID | ord-5bd73b3ae294469c94967e9d748eb309 |
|---|
| Source note | uspto-grants-2007_07 |
|---|
