1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 54377676, compound

HRID 129745Notes

Reaction equation

HRID 129745 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][CH2:13][NH:14][CH2:15][C@@H:10]3[C:9]3[CH:16]=[CH:17][CH:18]=[CH:19][C:8]=3[CH2:7][C:6]=2[CH:20]=1.Br[CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]2[C:25]1=[O:34]>>[C:25]1(=[O:34])[N:24]([CH2:23][CH2:22][N:14]2[CH2:13][CH2:12][N:11]3[C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:20][C:6]=4[CH2:7][C:8]4[CH:19]=[CH:18][CH:17]=[CH:16][C:9]=4[C@H:10]3[CH2:15]2)[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]12

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 54384241HCID 54384241, compound

Product 1

HCID 54377676HCID 54377676, compoundYield 91%

Procedure

Following a procedure similar to that described in Preparation 14(a), but using (14bS)-8-fluoro-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine and N-(2-bromoethyl)phthalimide, the title compound was obtained in a yield of 91%.

Sources & evidence

ORD record
ord-756a9c803026480d97beaf6f8835d04d
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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