1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 22857563, compound

HRID 129746Notes

Reaction equation

HRID 129746 reaction equation
[CH2:1]1[C@H:6]2[C:7]3[CH:19]=[CH:18][CH:17]=[CH:16][C:8]=3[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[N:12][C:11]=3[N:5]2[CH2:4][CH2:3][NH:2]1.Br[CH2:21][CH2:22][N:23]1[C:27](=[O:28])[C:26]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:25]2[C:24]1=[O:33]>>[C:24]1(=[O:33])[N:23]([CH2:22][CH2:21][N:2]2[CH2:3][CH2:4][N:5]3[C:11]4[N:12]=[CH:13][CH:14]=[CH:15][C:10]=4[CH2:9][C:8]4[CH:16]=[CH:17][CH:18]=[CH:19][C:7]=4[C@@H:6]3[CH2:1]2)[C:27](=[O:28])[C:26]2=[CH:29][CH:30]=[CH:31][CH:32]=[C:25]12

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 12989344(R)-Normirtazapine

Product 1

HCID 22857563HCID 22857563, compoundYield 47%

Procedure

Following a procedure similar to that described in Preparation 14(a), but using (14bR)-1,2,3,4,10,14b-hexahydropyrazino [2,1-a]pyrido[2,3-c][2]benzoazepine and N-(2-bromoethyl)phthalimide, the title compound was obtained in a yield of 47%.

Sources & evidence

ORD record
ord-cb9965cb02aa4ef79b7a6960c3092373
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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