Hydrazine → HCID 58914793, compound

HRID 1297499Notes

Reaction equation

HRID 1297499 reaction equation
NN.[C:3]([O:7][C:8]([NH:10][C:11]1[C:15]([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH3:23])=[CH:18][CH:17]=2)=[CH:14][N:13]([CH2:24][CH2:25][CH2:26][N:27]2C(=O)C3C=CC=CC=3C2=O)[CH:12]=1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>CCO>[NH2:27][CH2:26][CH2:25][CH2:24][N:13]1[CH:14]=[C:15]([C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH3:23])=[CH:18][CH:17]=2)[C:11]([NH:10][C:8]([O:7][C:3]([CH3:4])([CH3:6])[CH3:5])=[O:9])=[CH:12]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 58914800HCID 58914800, compound

Product 1

HCID 58914793HCID 58914793, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine (5 eq) was added to a solution of (tert-butoxy)-N-{1-[3-(1,3-dioxobenzo[c]azolin-2-yl)propyl]-4-(4-ethylphenyl)pyrrol-3-yl}carboxamide (1 eq) in abs. EtOH at 50° C. for 2 hours. The reaction developed a white precipitate which was filtered off. The EtOH was concentrated under reduced pressure. The residue was taken up in CH2Cl2 and the precipitate was filtered again. The organic solution was evaporated to a yellow solid containing product and solvent. Assumed a quantitative yield.

Workup

  1. filtrationwas filtered off
  2. concentrationThe EtOH was concentrated under reduced pressure
  3. filtrationthe precipitate was filtered again
  4. customThe organic solution was evaporated to a yellow solid
  5. additioncontaining product and solvent

Sources & evidence

ORD record
ord-1b70c5b89fdf4c0188dc3a507c7ab31f
Source dataset
uspto-grants-2007_07
Patent number
US07250443B2

Reaction notes

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