HCID 6610570, compound → HCID 53845749, compound

HRID 129750Notes

Reaction equation

HRID 129750 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[NH:11][C@H:10]([C:12]([OH:14])=O)[CH2:9][S:8]2)[CH:2]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH:21]([N:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][NH2:37])[CH2:30][CH2:29]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH:21]([N:28]1[CH2:29][CH2:30][N:31]([CH2:34][CH2:35][CH2:36][NH:37][C:12]([C@@H:10]2[CH2:9][S:8][CH:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[NH:11]2)=[O:14])[CH2:32][CH2:33]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 6610570HCID 6610570, compoundHCID 19370341HCID 19370341, compound

Product 1

HCID 53845749HCID 53845749, compoundYield 16%

Procedure

The title compound was prepared in a yield of 16% in a similar manner to that described in Example 17 by reacting 2-(3-pyridyl) thiazolidine-4(R)-carboxylic acid and 4-[α-(2-pyridyl)benzyl]-1-(3-aminopropyl)piperazine (prepared as described in Preparation 41').

Workup

  1. customprepared
  2. customas described in Preparation 41')

Sources & evidence

ORD record
ord-07e7f41d73034fef9884521b1e59cea4
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Reaction notes

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