HCID 136065296, compound → HCID 136065301, compound

Participants

Reaction Steps

A solution of tert-butyl 4-{N-[(6RS)-2-methoxymethyl-4-oxo-3,4,7,8-tetra-hydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoate (0.069 g, 0.15 mmol) in dichloromethane (1 ml) and trifluoroacetic acid (3 ml) was stirred at room temperature for 1 hour and 10 min, then the solvents were removed in vacuo. The residue was triturated with diethyl ether and the precipitate was collected by filtration, washed with diethyl ether and dried in vacuo over P2O5 to afford the title compound as the tifluoroacetate salt: 0.061 g, m.p. 225° C. (dec); 1H-NMR (250 MHz, DMSO-d6, TMS) 2.23, 2.53 (obscured by DMSO peak) (2×m, each 1H, 7-H), 2.90-3.20 (m, 3H, C≡CH, 8-H), 3.34 (s (obscured by the H2O peak), 3H, OCH3), 3.97 (ABq, J=18.0 Hz, 2H, CH2C≡C), 4.32 (s, 2H, 2-CH2), 5.79 (t, J=8.1 Hz, 1H, 6-H), 7.03 (d, J=9.02 Hz, 2H, 3′, 5′-H), 7.58, (s, 1H, 9-H), 7.81 (m, 3H, 5-H, 2′, 6′-H), 12.17 (s, 1H, N3-H); MS (ESI, m/z) 426 {(M+Na)+, 25%}, 404 {(M+H)+, 70%}.

Provenance & Evidence